“You’re all scared of each other thats what.” This quote from Curley’s wife clearly demonstrates the key theme of isolation articulated by the author John Steinbeck. Isolation is one of the main themes in Of Mice And Men, this is demonstrated almost instantly as the book starts, the town that George and Lenny are going to so they can get a job is named Soledad, which when translated from spanish to english it becomes solitude. Steinbeck almost instantly sets the layout for the story and the ideas that will be presented throughout the book by literally sending his main characters to loneliness.